T-cell Differentiation: MHC Class I's Sweet Tooth Lost on Maturity
نویسنده
چکیده
The addition of sialic acid to O-linked glycans of the T-cell co-receptor CD8 is regulated during thymocyte differentiation. Two recent papers have shown that this glycosylation changes the avidity of the interaction between CD8 and MHC class I proteins, potentially altering signalling thresholds in thymocyte differentiation.
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عنوان ژورنال:
- Current Biology
دوره 12 شماره
صفحات -
تاریخ انتشار 2002